Home » Abstracts » PTM & Glycoproteomics » Tackling anthracycline-induced cardiotoxicity by unbiased open-search analysis of protein posttranslational modifications

Tackling anthracycline-induced cardiotoxicity by unbiased open-search analysis of protein posttranslational modifications

PTM & Glycoproteomics

Abstract #310 Posted on28 March 202524 April 2025 24 April 2025 22h46

Author(s)

Inmaculada Jorge1 (Presenting Author) | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
José Manuel Rodríguez | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Víctor Manuel Guerrero-Sánchez | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, France
Cristina Amparo Devesa | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Carlos Galán | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Anabel Díaz-Guerra | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Laura Cádiz | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Borja Ibánez | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Emilio Camafeita | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain
Jesús Vázquez | Centro Nacional de Investigaciones Cardiovasculares (CNIC) | Melchor Fernández Almagro, 3, 28029, Madrid, Spain

Abstract

Anthracyclines remain the first-line treatment for many cancer types. However, anthracycline-induced cardiotoxicity (AIC) leads to irreversible cardiac injury in a significant proportion of patients. Despite being recognized for years, the mechanisms underlying AIC-triggered cardiac damage are still not fully understood, leaving a gap in effective therapies to prevent or reverse this harmful side effect. To shed light on the molecular events underlying AIC, we have carried out the first systematic, hypothesis-free study of the protein posttranslational modifications (PTMs) induced by doxorubicin administration in pig and mouse myocardial tissue. For that, we have used a novel integrative workflow that automatically captures multiple layers of PTM-related information, leveraging the publicly available applications PTM-Compass and iSanXoT.
In both pigs and mice, results highlight the accumulation of oxidative PTMs in specific protein regions upon parenteral doxorubicin administration. These hypermodified regions were enriched in several oxidative modifications affecting mainly Met, Trp, and Cys, which were thus regarded as hyperoxidized residues. Cardiac muscle contraction proteins were the main target of these AIC-triggered oxidative PTMs. We plan to use this first detailed map of the PTM changes that take place in the heart upon anthracycline administration as an indicator of the oxidative damage level caused by AIC.

Abstract N°

Review committee

Sélectionnez le(s) utilisateur(s) chargé(s) de la revue de cet abstract.

Communication type

Speaker abstract
Oral presentation
Flash communication
Poster

Communication status

Accepted
Rejected

Final abstract N°

Note globale

Abstract content *

Max 2000 characters. Line breaks are supported.

Author(s) informations *

1	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
2	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
3	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
4	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
5	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
6	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
7	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
8	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
9	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
10	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *
1	First name * Last name * email * Presenting author * At least and only one presenting author must be selected per abstract Presenting author Do you want this email to appear in the book of abstracts? If you refuse, only the administrators and the review commitee will have access to this email as part of the review process. YesNo Laboratory * Address * ZIP code * City * Country *

Add another author

Are you an ECR? *

<7 years after last degree

Are you a Junior PI? *

If you have started your own group less than 3 years ago and are not chosen by the scientific committee for a talk, you will have the opportunity to give a keynote during an ECR parallel session

Are you an invited speaker? *

Consent *

By submitting this form I agree
- that the administrators use my personal information for the abstract revision process.
- that my name, affiliation and abstract content may be publicly displayed.

Captcha